Cortisol Manager is formulated with stress-reducing ingredients and botanicals to promote relaxation, help alleviate fatigue, and support healthy cortisol levels. By balancing cortisol levels, Cortisol Manager can help reduce stress, which supports a restful night’s sleep without diminishing daytime alertness.

• The stress hormone stabilizer
• promotes relaxation
• Helps alleviate fatigue
• Supports healthy cortisol levels

Each tablet contains:
Medicinal Ingredients:
Stress-reducing proprietary blend: ashwagandha (withania somnifera) (sensoril brand) root and leaf extract and l-theanine (suntheanine brand) 250mg, cortisol-reducing proprietary blend: magnolia (magnolia officinalis) bark extract standardized to contain 2% honokiol and 1% magnolol and epimedium (epimedium koreanum) aerial part extract 225mg and phosphatidylserine (soy) 50mg.

Non-Medicinal Ingredients:
Cellulose, hydroxypropyl methylcellulose, sodium carboxymethyl cellulose, stearic acid, magnesium stearate, silicon dioxide, titanium dioxide colour and glycerin.

Adults: Take 1 tablet before bedtime, or as recommended by your healthcare professional. Increase to 2 tablets during times of high stress. For every night use.

Do not use if pregnant. If nursing, diabetic, or taking any prescription drugs, consult your healthcare professional prior to use. Avoid taking in case of known allergy to any of the ingredients in the product. Do not use if safety seal is broken. Keep out of reach of children.

Bioclinic Somno-PRO Tropical Breeze, L-Theanine, 5-hydroxytryptophan (5-HTP) and melatonin have all been shown to independently improve sleep quality and quantity, and/or lessen anxiety. L-Theanine is an amino acid found almost exclusively in tea, which influences the central nervous system through a number of mechanisms, primarily by influencing levels of the neurotransmitters dopamine, gamma-aminobutyric acid (GABA), serotonin, norepinephrine, and glutamate. These effects cause a significant increase in alpha brain wave activity, indicative of a state of wakeful relaxation, increased performance under stress, improved learning, and concentration, as well as decreased anxiety.

5-HTP is the intermediary between L-tryptophan and serotonin, a key neurotransmitter associated with sleep, mood and anxiety. 5-HTP bypasses the rate-limiting enzyme tryptophan hydroxylase, which normally limits the conversion of tryptophan to serotonin.

Melatonin is also closely related, and is formed by conversion of serotonin in the pineal gland. Known to regulate many biological rhythms, including the circadian cycle, melatonin has shown clinical benefit for inducing sleep or adjusting sleep cycles. Randomized trials have found it to reduce sleep onset latency and improve perceived quality of sleep, without impairing daytime psychomotor performance.

• Reduces anxiety and nervous system excitation, which can inhibit sleep
• Safe without the side effects of prescription or over-the-counter (OTC) medications
• Convenient and fast-acting
• Delicious tropical fruit flavoured chewable
• Addresses every facet of insomnia: difficulty initiating sleep, difficulty maintaining sleep, waking too early in the morning and waking groggy

Each chewable tablet contains:
Medicinal Ingredients:
Suntheanine® l-theanine 100mg, l-5-hydroxytryptophan (5-HTP) (griffonia simplicifolia) (seed) 15mg and melatonin 1.5mg.

Non-Medicinal Ingredients:
Organic cane juice, stearic acid, xylitol, silica, natural flavors (pineapple, banana, pomegranate, mango, passion fruit, peach), citric acid and vegetable grade magnesium stearate (lubricant).

Adults: Chew 2 tablets 30-45 minutes before bedtime or as directed by a healthcare practitioner.

While no specific contraindication exists or is predicted, data is lacking for use during pregnancy, lactation, and in children, and the dosage may need to be reduced for those less than 18. Consult a healthcare practitioner prior to use if you have a hormonal disorder, diabetes, liver or kidney disease, cerebral palsy, seizure disorders, migraine, depression and/or hypertension or if you have scleroderma. Do not drive or use machinery for 5 hours after taking melatonin. Do not use if safety seal is broken. Keep out of reach of children.

Genestra Melatonin Spray provides melatonin to help control the body’s natural sleep cycle. Melatonin is a hormone that is normally released at night from the pineal gland. Research demonstrates that supplementation with melatonin significantly improves sleep onset, total sleep time and sleep quality when compared to placebo treatments.

Supplementation with melatonin before sleeping has been shown to improve sleep quality and duration among shift workers, who often experience less sleep than daytime workers. Melatonin intake at local sleep times can also support the sleep-wake cycle after international travel. As melatonin levels significantly decrease with age, its supplementation can help promote healthy sleep patterns in older individuals.

NPN: 80029769

• Promotes healthy sleep patterns
• Supports the body’s natural sleep-wake cycle
• Improves sleep onset and quality
• Promotes recovery after shift work and international travel
• Delicious natural spearmint flavour

Melatonin 3mg.

Non-Medicinal Ingredients:
Purified water, glycerin, ethanol, xylitol, natural spearmint flavor, citric acid, potassium sorbate, rebaudioside A (stevia leaf extract) and menthol.

Adults: Take three sprays orally, once daily at or before bedtime, or as recommended by your healthcare practitioner. For adult use only.

Do not drive or use machinery for five hours after taking melatonin. If you are pregnant or breastfeeding; or if you are taking immunosuppressive drugs, do not use it. Safety-sealed for your protection and for product freshness. Do not use if outer seal is missing or broken. Store in a cool, dry place. Keep out of reach of children.

 

AOR Ortho Sleep, Did you know that irregular sleep patterns are being called the new silent killer, being as detrimental to health as stress and poor diet? Studies show that those who chronically get less sleep than the “golden” 7-8 hours are at a higher risk for a number of diseases, are prone to weight gain, and are less able to deal with the effects of stress. People suffering from insomnia spend less time in deeper levels of sleep, wake up more often, and experience a reduction in REM sleep. In addition to stress, insomnia can be caused by a variety of other factors, including anxiety, poor diet, or a disruption of the body's internal clock - such as jet lag, all-night study sessions, or changing work hours.
Ortho Sleep™ is an award-winning premium sleep and relaxation formula. The most important neurotransmitters known to regulate the sleep-wake cycle have been combined with the most powerful herbs traditionally used to promote sleep, yielding a natural sleep remedy like no other. 

Ortho Sleep contains a carefully formulated blend of nutrients and compounds that have been shown to be effective in combating insomnia, restoring a proper circadian rhythm, and promoting healthy, restful sleep. These include relaxing neurotransmitters GABA and melatonin, as well as 5-HTP, a serotonin precursor to reduce feelings of worry, especially when trying to fall asleep. The formula further includes the amino acid L-theanine as well as valerian root, passionflower extract, and lemon balm, all of which possess relaxing properties and work to increase the activity of GABA in the brain.

Ortho Sleep is perfect for those who have difficulty falling asleep, staying asleep, or feeling rested upon waking. Ortho Sleep may help in cases of jet-lag, shift work, or insomnia. If you have used the individual ingredients found in the formula with no success, Ortho Sleep may offer a more powerful natural solution.
 

A Natural Solution to Promote Restful Sleep
The most comprehensive, natural sleep formula available
Helps one fall asleep, stay asleep, and wake up feeling refreshed
Bronze winner of the 2013 Optimyz Best of the Best Awards

Supplement Facts
Amount: 2 Capsules

GABA (gamma-aminobutyric acid): 100 mg
L-Theanine: 200 mg
L-5-Hydroxytryptophan (Griffonia seed): 100 mg
Melatonin: 3 mg
Valerian root (0.8% valerenic acid): 150 mg
Passionflower extract (aerial parts): 32 mg
Lemon balm extract (aerial parts)*: 300 mg

*Cyracos is a registered trademark of Naturex, Inc.

maltodextrin, gum Arabic, silicon dioxide. Capsule: hypromellose.

AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.

Take 1-2 capsules before bedtime with/without food, or as directed by a qualified health care practitioner

Consult a health care practitioner prior to use if taking carbidopa or drugs/supplements with serotonergic activity.  These may include but are not limited to, L-tryptophan, S-adenosylmethionine (SAMe), St. John’s Wort, antidepressants, pain killers, cough/cold medication containing dextromethorphan, anti-nausea, anti-blood pressure, and anti-migraine medication. 

Discontinue use and consult a health care practitioner if you show signs of weakness, oral ulcers, or abdominal pain accompanied by severe muscle pain or if you experience skin changes.  Some people may experience gastrointestinal disturbances such as diarrhea, nausea, vomiting, and abdominal pain as well as drowsiness.

Do not use it if you have scleroderma. Hypersensitivity (e.g. allergy) has been known to occur; in which case, discontinue use. Do not drive or use machinery for 5 hours after taking Ortho Sleep.  Exercise caution if engaging in activities requiring mental alertness.

Do not take Ortho Sleep if pregnant, nursing, trying to conceive, or taking immunosuppressive drugs. Not to be used by individuals under the age of 18 or those with a medical condition such as a hormonal disorder, diabetes, liver or kidney disease, cerebral palsy, seizure disorders, migraine, depression, and or hypertension. Consult a health care practitioner if sleeplessness persists continuously for more than 3 weeks (chronic insomnia).

Consult a health care practitioner if symptoms persist or worsen. Consumption of alcohol, other medications, or health products with sedative properties is not recommended.

5-HTP stands for L-5-hydroxytryptophan, which comes from the amino acid tryptophan found in many proteins and the seeds of an African plant known as Griffonia simplicifolia. 5-HTP is primarily used to support mood through its ability to increase serotonin – the neurotransmitter associated with happiness – and the neurohormone melatonin. It can also be used for several conditions where serotonin is believed to play an important role.

5-HTP has been compared to various antidepressants and has been found to be as effective and faster-acting with fewer side effects. Since serotonin and melatonin are involved in regulating the sleep/wake cycle, 5-HTP can enhance sleep quality. Additionally, research supports a role for 5-HTP in reducing headaches and the symptoms of fibromyalgia. Several clinical trials with 5-HTP have confirmed significant improvements in symptoms associated with fibromyalgia including pain, morning stiffness, nervousness, and fatigue.

Ultimately, those who suffer with mood imbalances such as low mood and anxiety, or from migraines, fibromyalgia or sleep disorders may benefit from taking 5-HTP.

• Provides 5-HTP, an absorbable precursor to serotonin
• Improves sleep patterns & helps alleviate migraines
• Flexible dosing options for varying needs

Consult a health care practitioner prior to use if taking carbidopa or drugs/supplements with serotonergic activity, including, but not limited to, L-tryptophan, SAMe, St. John’s Wort, antidepressants, pain killers, cough/cold medication containing dextromethorphan, anti-nausea medication or anti-migraine medication. Some people may experience gastrointestinal disturbances such as diarrhea, nausea, vomiting and abdominal pain. May cause drowsiness; exercise caution if driving or operating heavy machinery or engaging in activities requiring mental alertness.

Discontinue use and consult a health care practitioner if you experience skin changes, weakness, oral ulcers, or abdominal pain accompanied by severe muscle pain. Do not use if you have scleroderma, if you are pregnant, breastfeeding, or trying to conceive. Not to be used by individuals under the age of 18 or those with a medical condition. Consult a health care practitioner if symptoms persist or worsen or for use beyond one year.

Pascoe Pascofemin is a homeopathic remedy to relieve symptoms associated with menopause, PMS, and other hormonal disturbances such as hot flashes, sleep disorders, bloating, mood swings, irritability, breast tenderness, abdominal pain, and headaches. It is suitable for adults and children 12 years and up and made with naturally sourced medicinal ingredients including Agnus castus, Pulsatilla, Lilium tigrinum, and Cimicifuga.

Pascofemin Drops include the ingredient Fraxinus Americana. This key ingredient is widely used to help treat symptoms typically associated with menopause, such as hot flashes and mood changes. As well, it is also widely used to help treat uterine fibroids. The other active ingredients work to help relieve menstrual problems and other hormonal disturbances. The oral drops should be taken diluted in a little water.

Homeopathic remedy used to relieve symptoms associated with menopause PMS and other hormonal disturbances such as:

• hot flashes
• sleep disorders
• bloating
• mood swings
• irritability
• breast tenderness
• abdominal pain and headaches

Each tablet contains:
Agnus castus 2X 0.2g, cimicifuga 3X 0.2g, aletris farinosa 3X 0.075g, pulsatilla 4X 0.075g, heliconias dioica 3X 0.075g, lilium tigrinum 3X 0.075g, Ignatia 4X 0.075g, senecio aureus 5X 0.075g, caulophyllum 2X 0.075g and fraxinus americana 3X 0.075g. Contains 34% vol. alcohol.

Adults and children 12 years of age and over: 10-30 drops 3 times daily in a little water.

Consult a healthcare practitioner before use if pregnant or breastfeeding. Contraindicated in children under 12 years of age.

Ashwagandha is traditionally used in traditional Ayurvedic medicine as a Rasayana (rejuvenative tonic) to relieve general debility, especially during convalescence or old age; as a sleep aid; to balance aggravated Vata (nervine tonic, sedative); and for memory enhancement. Ashwagandha is also used for arthritis, anxiety, and insomnia. It is also a general tonic and adaptogen, increasing resistance to environmental stress.

• Used for arthritis, anxiety, and insomnia

Each ml contains:
Medicinal ingredient:
Ashwagandha (Withania somnifera, root) 250mg.

Non-Medicinal Ingredients:
Distilled water and certified organic alcohol.
 

Adults: Take 2.66ml (80 drops) 3 times daily in a little water on an empty stomach.

Consult a health care practitioner before use if you are pregnant. Consumption with alcohol, other drugs or natural health products with sedative properties is not recommended. Keep out of reach of children. Do not use if seal is broken. Store at room temperature.

Helps to promote healthy mood balance and used as a sleep aid. Use for a minimum of 1 week to see beneficial effects. Consult a health-care practitioner for use beyond one year.

NPN: 80060101

• Enhances serotonin production

L-5-Hydroxytryptophan (Griffonia simplicifolia) 50mg
Vitamin B6 (Pyridoxal 5'-Phosphate) 3.4mg

Other Ingredients: Hypromellose Capsule, Leucine, Microcrystalline Cellulose, Silicon Dioxide

Take 2-4 capsules daily or as recommended by a health professional. Take 30-45 minutes before bedtime.

If you are pregnant or breastfeeding, consult a health professional prior to use. If symptoms persist or worsen, consult a health professional. Consult a health professional if sleeplessness persists continuously for more than 3 weeks (chronic insomnia). Consult a health professional prior to use if you are taking carbidopa or drugs/supplements with serotonergic activity.

These may include, but are not limited to, L-tryptophan, S-adenosylmethionine (SAMe), St. John’s wort, antidepressants, pain killers, over the counter cough and cold medication containing dextromethorphan, anti-nausea medication and anti-migraine medication. Some people may experience diarrhea, nausea, vomiting and abdominal pain. Discontinue use and consult a health professional if you show signs of weakness, oral ulcers, or abdominal pain accompanied by severe muscle pain or if you experience skin changes. Do not use if you have scleroderma. Some people may experience drowsiness. Exercise caution if operating heavy machinery, driving a motor vehicle or are involved in activities requiring mental alertness.

Bioclinic Melatonin Time Release,  Melatonin plays a major role in the circadian regulation of the sleep-wake cycle and has proven critically important for both initiation and quality of sleep, with supplementation improving sleep in healthy individuals and in those with insomnia, as well as preventing phase shifts due to jet lag or rotating work schedules. Time release melatonin improves not only the initiation of sleep, but its longer plasma half-life helps to maintain and improve the quality of sleep.

Melatonin is particularly effective in older individuals, regardless of endogenous melatonin levels, in both the short and long term, with improvements in sleep quality, morning alertness, sleep onset latency and quality of life, with no relevant adverse effects or dependency. It has been shown to improve sleep quality in children with diverse sleep complaints, including delayed sleep phase syndrome and impaired sleep maintenance, or other sleep-related disorders. Melatonin has diverse physiological benefits, including improved bone mineral density in those with osteopenia, and lowered hepatic enzymes in those with non-alcoholic steatohepatitis. Time-release melatonin has had clinical improvements in mood in those with sleep disturbances, as well as cognitive performance in those with Alzheimer’s disease.

• Clinically shown to improve sleep quality, morning alertness, sleep onset latency and quality of life, with no adverse effects of dependency
• Supplementation linked to improved mood and cognitive function among those with impaired sleep
• Provides 5mg time-released melatonin per tablet
• Time-release formulation sustains plasma levels for a longer period, enhancing sleep initiation, maintenance, and quality
• Suitable for vegetarians/vegans

Each tablet contains:
Medicinal ingredient:
Melatonin (non-animal source) 5mg. 

Non-Medicinal Ingredients:
Dibasic calcium phosphate dihydrate, microcrystalline cellulose, carbohydrate gum [cellulose] and vegetable grade magnesium stearate (lubricant).

Adults: Take 1-2 tablets per day at or before bedtime, or as directed by a healthcare practitioner. Jet Lag: Take once a day at bedtime after darkness has fallen, while traveling, and at destination until adaptation to the new daily pattern. For occasional short-term use. Do not drive or use machinery for 5 hours after taking melatonin. For use beyond 4 weeks, consult a healthcare practitioner.

Consumption with alcohol, other medications or natural health products with sedative properties is not recommended. If you are taking one of the following medications, consult a healthcare practitioner prior to use: anticoagulant, anticonvulsant, blood pressure medications, immunosuppressive medications, sedative, hypnotic or psychotropic medications, or steroids. If you have one of the following conditions, consult a healthcare practitioner prior to use: asthma, cardiovascular disease, chronic kidney disease, depression, diabetes or hypoglycemia, hormonal disorder, immune system disease, liver disease, migraine, or seizure disorders. If symptoms persist continuously for more than 4 weeks (chronic insomnia) consult a healthcare practitioner. Mild gastrointestinal symptoms (such as nausea, vomiting, or cramping) have been known to occur, in which case discontinue use. Rare allergic reactions have been known to occur, in which case discontinue use. Do not use if you are pregnant or breastfeeding. Keep out of reach of children. Do not use if safety seal is broken.

Pascoflair from Pascoe, made with 425mg dry extract of passiflora incarnate (passionflower) per tablet, has the highest dose of Passionflower extract on the market. It naturally calms and declutters your mind, helping you fall asleep and stay sound asleep through the night. Pascoflair is traditionally used in herbal medicine as a sleep aid in cases of restlessness and insomnia due to mental stress.

Passionflower (passiflora incarnate) is an herbal remedy, which has been known for centuries as an excellent treatment to help with sleep disturbances. It helps you sleep by turning off all the running thoughts that are going through your mind at bedtime. The mind can relax, which is then followed by the body, and as a result, sleep will follow.

• Traditionally used in Herbal Medicine as a sleep aid (in cases of restlessness or insomnia due to mental stress)

Medicinal Ingredients:
Dry extract (5-7:1) of passiflora incarnata L. 425mg (passionflower), equivalent to 2.125g – 2.975g aerial parts. Extractant: ethanol 50% (V/V).

Non-Medicinal Ingredients:
Sucrose and glucose

Adults and children 13 years of age and over: 1 tablet, 2 times daily. Pascoflair should be swallowed whole with sufficient liquid (preferably a glass of water), and the doses should be spread evenly throughout the day.

Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding. If symptoms persist or worsen, consult a healthcare practitioner. Avoid taking in case of known allergy to any of the ingredients in the product. Do not use if safety seal is broken. Keep out of reach of children.

Valerian Complex contains Valerian, Passion Flower and Ziziphus jujuba var.spinosa. This combination of herbs contains many compounds including iridoids (known as valepotriates), an essential oil, cyclopentane sesquiterpenes (including valerenic acid), flavonoids and dammarane-type saponins called jujubosides.

NOTE: All MediHerb online purchases require a health advisor consult. A natural health advisor from our team will call you directly after your purchase for a quick tele-consultation.

• Relieves mild nervous tension
• Obtains relief from occasional sleeplessness
• Promotes relaxation
• Eases the effects of temporary or occasional stress 

Calcium 60mg, valerian root & rhizome 5:1 extract from valeriana officinalis root & rhizome 700mg 140mg,
passion flower herb 5:1 extract from passiflora incarnata herb 500mg 100mg 
jujube seed 10:1 extract from ziziphus jujuba var. spinosa seed 900mg 90mg.

Non-Medicinal Ingredients:
Calcium phosphate, cellulose, sodium starch glycollate, magnesium stearate, maltodextrin, hypromellose and silica.

Take 1 tablet 2 - 4 times daily, or as directed.

Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding. If symptoms persist or worsen, consult a healthcare practitioner. Avoid taking in case of known allergy to any of the ingredients in the product. Do not use if safety seal is broken. Keep out of reach of children.

NOTE: All MediHerb online purchases require a health advisor consult. A natural health advisor from our team will call you directly after your purchase for a quick tele-consultation.

• Calms the nerves
• Eases the effects of mild tension and stress
• Promotes relaxation and sleep
• Supports muscle relaxation

Kava root 7:1 water extract from Piper methysticum root 3.2g (containing kavalactones 50mg) 455mg.

Non-Medicinal Ingredients:
Cellulose, maltodextrin, magnesium stearate, silicon dioxide, hypromellose, sodium starch glycollate and calcium phosphate.

Take 1 tablet 2 – 3 times daily, or as directed.

Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding. If symptoms persist or worsen, consult a healthcare practitioner. Avoid taking in case of known allergy to any of the ingredients in the product. Do not use if safety seal is broken. Keep out of reach of children.

Brain Calm is an effective blend of critical amino acids and herbs that promote relaxation and sleep. GABA (gamma-aminobutyric acid) is an amino acid that functions as an inhibitory neurotransmitter in the brain. Most neurotransmitters, such as acetylcholine and noradrenaline, promote a feeling of wakefulness and alertness, however GABA acts by blocking these –excitatory” neurotransmitters to promote relaxation in the brain.

By promoting relaxation, GABA has been shown to help sleep irregularities such as the inability to fall asleep or waking during the night. Additionally, Brain Calm contains Passion flower, which is used traditionally in Herbal Medicine as a sleep aid, especially in times of restlessness or sleeplessness due to mental stress. Plant compounds of Passion flower exert effects in the brain by binding to GABA receptors, promoting a relaxation effect similar to GABA itself.

NPN: 80031289

• Temporarily promotes relaxation
• Passionflower is traditionally used in herbal medicine as a sleep aid

Inositol 500mg,
GABA (gamma-aminobutyric acid) 100mg,
passionflower (passiflora incarnata) aerial parts extract (6:1, 600mg dried equivalent) 100mg and l-glycine 50mg.

Non-Medicinal Ingredients:
Hypromellose (capsule), cellulose, magnesium stearate and silica.

Adults: Take 1 capsule before dinner or at bedtime, or as directed by your healthcare practitioner. Consult a healthcare practitioner for use beyond 12 weeks.

Consult your healthcare practitioner prior to use if you are pregnant, breastfeeding, taking anti-anxiety or blood pressure medication, or have epilepsy. Consult your healthcare practitioner if sleeplessness persists continuously for more than 3 weeks or if symptoms persist or worsen. Consumption with alcohol, other medications or natural health products with sedative properties is not recommended. Some people may experience drowsiness. Exercise caution if operating heavy machinery, driving a motor vehicle or involved in activities requiring mental alertness. Hypersensitivity has been known to occur, in which case, discontinue use. Store in a cool dry area. Do not use if seal is missing or broken. Keep out of reach of children.

Help promote healthy testosterone production in males. Help increase resistance to stress/anxiety in individuals with a history of chronic stress, thereby improving their overall quality of life. Provide athletic support as a workout/exercise supplement.

Each ml contains: Medicinal Ingredients (300 mg per capsule): A 12:1 concentration, each capsule contains the equivalent of 3600 mg of dried Certified Organic Ashwagandha (Withania somnifera) standardized to 5% withanolides (alcohol free).

We use KSM-66®–a clean, sustainably sourced ashwagandha that is backed by research and clinical studies. Non-Medicinal Ingredients: Magnesium stearate Hypromellose (vegicap) Milk Products CONTAINS NO: egg, wheat, soy, artificial preservatives, artificial colours, artificial sweeteners

Take 1 capsule 2 times daily on an empty stomach.

Consult a health care practitioner before use if you are pregnant or breastfeeding. Consumption of alcohol, other drugs or health products with sedative properties is not recommended. Consult a health care practitioner if you have benign prostate hypertrophy and/or prostate cancer. Keep out of reach of children. Do not use if the seal is broken. Store at room temperature.

Douglas Melatonin sublingual tablets each contain 3mg of high-purity melatonin. Purity and potency of each batch of Melatonin tablets are verified by an independent, certified analytical laboratory.

Melatonin is a hormone synthesized from the amino acid tryptophan by the pineal gland in the brain. The perception of daylight in the eyes is a signal for the pineal gland to inhibit melatonin synthesis and release. At night or in a dark environment, the body’s melatonin production rises, which is thought to be responsible for promoting sleep. Therefore, most of the research on melatonin has focused on its role in maintaining normal sleep/wake rhythms.

Research has shown that melatonin supplementation helps reset the body’s sleep-wake cycle, an aspect of the circadian rhythm. It helps reduce the time it takes to fall asleep (sleep onset latency) in people with delayed sleep phase disorder, who often experience difficulty falling asleep at desired or conventional times. Melatonin also increases the total sleep time in people suffering from sleep restriction or altered sleep schedule, including shift-work and jet lag, and helps to relieve the daytime fatigue associated with jet lag.

Nocturnal melatonin production is highest in children and begins to decline from adolescence until it is virtually absent in the elderly. This sublingual tablet will rapidly dissolve when placed under the tongue and the bisect tablet allows for easy dosing modifications. 

NPN: 80001069

•  Helps increase the total sleep time in people from suffering sleep restriction or altered sleep schedule

Melatonin 3mg.

Non-Medicinal Ingredients:
Cellulose‚ fructose‚ dicalcium phosphate and vegetable stearate.

Adults: Take 1 tablet 20 minutes before bedtime or as directed by your healthcare practitioner only. Allow tablet to dissolve in mouth or with water or juice and then swallow.

 Not to be taken by pregnant or lactating women. If you are taking MAO inhibitors‚ immunosuppressant drugs‚ anticoagulation therapy‚ or antihypertensive medication‚ or have autoimmune‚ seizure‚ psychiatric or depressive disorder consult your healthcare practitioner before using this product. Long-term use of melatonin has not been studied. May cause drowsiness. Do not use before or while operating a motor vehicle or heavy machinery. Do not use if safety seal is broken. Keep out of reach of children.

Black Cohosh is the most researched herb for the treatment of menopausal symptoms and the replacement of standard hormone replacement therapy (estrogen and progestins). It is effective in the treatment of the following menopausal symptoms: hot flashes, heavy perspiration, headaches, heart palpitations, depression, sleep disturbances, vaginal atrophy (thinning of the vaginal walls causing painful intercourse), vaginal dryness, nervousness, irritability and loss of concentration. In 2004 researchers discovered that black cohosh has no hormone action and that it works on the vascular system to reduce hot flashes and night sweats. As a result studies were then performed using black cohosh along with tamoxifen in women with estrogen receptor positive to dramatically reduce hot flashes. Black cohosh is safe and non-estrogenic.

• Reduces hot flashes
• Prevents night sweats
• Relieves irritability and nervousness
• Improves mood and concentration
• Reduces vaginal atrophy and dryness
• Eases leg cramps
• Aids restful sleep
• Includes 300mg of sage

Each capsule contains:
Medicinal Ingredients:
Dong quai extract (angelica sinensis) (4:1 from 400mg of dong quai) 100mg, black cohosh (cimicifuga racemosa) extract (2mg of triterpene glycosides measured at 27-deoxyactein) 80mg, chasteberry extract (vitex agnus-castus) (0.6% aucubin) (10:1 from 800mg of chasteberry) 80mg gamma-oryzanol (from rice bran oil) 75mg, hesperidin (citrus sinensis, pericarp) 75mg and sage leaf (salvia officinalis) 75mg.

Take 2 capsules at breakfast and 2 at bedtime or as directed by a health care practitioner.

Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding. If symptoms persist or worsen, consult a healthcare practitioner. Avoid taking in case of known allergy to any of the ingredients in the product. Do not use if safety seal is broken. Keep out of reach of children.

Pasconal is a homeopathic remedy for sleep disturbances, physical and mental exhaustion, nervousness and restlessness.

This unique combination contains four homeopathic active substances - avena sativa (Oatstraw), strychonos ignatii (Bean of St. Ignatius), tarantula hispanica (tarantel), valeriana officinalis (valeriana) - and is approved by Health Canada for children aged 1 or over and adults suffering from sleep disorders with nervousness.

Homeopathic remedy for:

• sleep disturbances
• physical and mental exhaustion
• nervousness and restlessness

Each gram contains:
Avena sativa Ø 250mg, valeriana Ø 250mg, ignatia 4X 250mg and lycosa (Tarantula) 5X 25mg. Contains 48% vol. alcohol.

Dosing for daytime calming: 
Adults and children 12 years of age and over: 20-30 drops, 1-3 times a day. Children 6 - 11 years old: 10-15 drops 1-3 times a day. Children 1 - 5 years old: 5-10 drops 1-3 times a day.

Dosing for difficulty going to sleep (To be taken in the evening):
Adults and children 12 years of age and over: 30-40 drops. Children 6 - 11 years old: 20-25 drops. Children 1 - 5 years old: 10-15 drops.

Contraindicated in children under 1 year of age. Consult a healthcare practitioner before using if pregnant or breastfeeding. If you experience persistent, unclear or new symptoms, see a health care practitioner because you may have a condition that requires medical evaluation.

Melatonin PR provides all of the benefits of Melatonin in a convenient prolonged-release tablet.

NPN: 80027990

• Helps increase the total sleep time in people suffering from sleep restriction or altered sleep schedule and reset the body's sleep-wake cycle

Melatonin 3mg.

Non-Medicinal Ingredients:
Cellulose, dicalcium phosphate dihydrate, ethylcellulose, stearic acid, magnesium stearate, silica and tablet coating (hypromellose, glycerin).

Adults: Take 1 tablet 1 hour before bedtime or as directed by your healthcare practitioner. Consult your healthcare practitioner for use beyond 4 weeks.

Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding. If symptoms persist or worsen, consult a healthcare practitioner. Avoid taking in case of known allergy to any of the ingredients in the product. Do not use if safety seal is broken. Keep out of reach of children.

Melatonin works with the body’s natural cycles to safely and effectively reset your “biological clock”, helping you fall asleep faster, increasing the quality and duration of sleep, supporting REM sleep, and reducing daytime fatigue. Natural Factors Melatonin, from non-animal sources, comes in a sublingual tablet to ensure fast, consistent absorption.

• Addresses occasional sleep disturbances including difficulty falling asleep, staying asleep, and waking too early
• Re-establishes a normal circadian sleep rhythm in anyone suffering from disrupted sleep patterns due to jet lag, shift work, or delayed sleep phase syndrome (DSPS)
• Improves sleep quality and duration, reducing daytime fatigue
• Helps with insomnia caused by age-related declines in melatonin in the elderly

Melatonin (non-animal source) 10 mg

Dissolve before swallowing, 1 tablet per day prior to bedtime, or as directed by a health professional.

Avoid taking in case of known allergy to any of the ingredients in the product. Consult a healthcare practitioner. Do not use if safety seal is broken. Keep out of reach of children.

L-Theanine, 5-hydroxytryptophan (5-HTP) and melatonin have all been shown to independently improve sleep quality and quantity, and/or lessen anxiety. L-Theanine is an amino acid found almost exclusively in tea, which influences the central nervous system through a number of mechanisms, primarily by influencing levels of the neurotransmitters dopamine, gamma-aminobutyric acid (GABA), serotonin, norepinephrine and glutamate. These effects cause a significant increase in alpha brain wave activity, indicative of a state of wakeful relaxation, increased performance under stress, improved learning and concentration, as well as decreased anxiety.

5-HTP is the intermediary between L-tryptophan and serotonin, a key neurotransmitter associated with sleep, mood, and anxiety. 5-HTP bypasses the rate limiting enzyme tryptophan hydroxylase, which normally limits the conversion of tryptophan to serotonin.

Melatonin is also closely related, and is formed by conversion of serotonin in the pineal gland. Known to regulate many biological rhythms, including the circadian cycle, melatonin has shown clinical benefit for inducing sleep or adjusting sleep cycles. Randomized trials have found it to reduce sleep onset latency and improve perceived quality of sleep, without impairing daytime psychomotor performance.

• Reduces anxiety and nervous system excitation, which can inhibit sleep
• Safe, without the side effects of prescription or over-the-counter (OTC) medications
• Enteric coated to reduce the risk of nausea
• Addresses every facet of insomnia: difficulty initiating sleep, difficulty maintaining sleep, waking too early in the morning, and waking groggy

Each softgel contains:
Medicinal Ingredients:
Suntheanine l-theanine 100mg, 5-hydroxy-l-tryptophan (L-5-HTP) (griffonia simplicifolia) (seed) 15mg and melatonin 1.5mg.

Non-Medicinal Ingredients:
Softgel (gelatin, glycerin, purified water), organic flaxseed oil, yellow beeswax, non-GMO sunflower lecithin and enteric coating (purified water, ethylcellulose, medium chain triglycerides, oleic acid, sodium alginate, stearic acid).

Adults: Take 2 softgels per day 30-45 minutes prior to bedtime or as directed by a healthcare practitioner. Consult a healthcare practitioner for use beyond 4 weeks. Do not take on an empty stomach.

Consult a health care practitioner prior to use if you have a hormonal disorder, diabetes, liver or kidney disease, cerebral palsy, seizure disorders, migraine, depression and/or hypertension. Consult a health care practitioner prior to use if you are taking carbidopa or drugs/supplements with serotonergic activity. These may include but are not limited to L-tryptophan, S-adenosylmethionine (SAMe), St. John’s wort, antidepressants, pain killers, over-the-counter cough and cold medication containing dextromethorphan, anti-nausea medication and anti-migraine medication. Consult a health care practitioner if sleeplessness persists continuously for more than 3 weeks (chronic insomnia), or if symptoms persist or worsen. Some people may experience diarrhea, nausea, vomiting and abdominal pain. Discontinue use if you show signs of weakness, oral ulcers, skin changes or abdominal pain accompanied by severe muscle pain. Do not use if you are taking blood pressure, immunosuppressive or sedative/hypnotic medication or if you are pregnant or breastfeeding or have scleroderma. Some people may experience drowsiness. Exercise caution if you are involved in activities requiring mental alertness. Do not drive or use machinery for 5 hours after taking this product. Keep out of reach of children.

Pascofemin is a homeopathic remedy to relieve symptoms associated with menopause, PMS, and other hormonal disturbances such as hot flashes, sleep disorders, bloating, mood swings, irritability, breast tenderness, abdominal pain, and headaches. It is suitable for adults and children 12 years and up and made with naturally sourced medicinal ingredients including agnus castus, pulsatilla, lilium tigrinum, and cimicifuga.

Homeopathic remedy used to relieve symptoms associated with menopause PMS and other hormonal disturbances such as:

• hot flashes
• sleep disorders
• bloating
• mood swings
• irritability
• breast tenderness
• abdominal pain and headaches

Each tablet contains:
Agnus castus 2X 30mg, cimicifuga 6X 30mg, aletris farinosa 3X 10mg, pulsatilla 4X 10mg, helonias dioica 3X 10mg, lilium tigrinum 3X 10mg, ignatia 4X 10mg, senecio aureus 5X 10mg and caulophyllum 2X 10mg.

Adults and children 12 years of age and over: 1-3 tablets 1-3 times a day. Acute: Take 1 tablet every 30-60 minutes no more than 6 times a day.

In the case of fever, in the absence of menstrual bleeding or prolonged bleeding please consult a healthcare practitioner. Consult a healthcare practitioner before using if you are pregnant or breastfeeding, or before using in children under 12 years. This homeopathic remedy contains lactose. Consult your healthcare practitioner if you are lactose intolerant.

Fast-acting relief for nervousness and acute stress, Natural Factors Stress-Relax 100% Natural GABA is a superior source and naturally produced form of the important brain compound gamma-aminobutyric acid (GABA). Convenient chewable tablets in tropical fruit flavour help to quickly promote relaxation and ease nervous tension.

• Reduces acute stress and nervousness, and quickly restores mental calmness
• Promotes mental clarity and physical relaxation without drowsiness
• Improves cognitive functions including learning performance, concentration and memory
• Controls stress-related eating and food cravings
• Improves sleep quality

Pharma GABATM 80 gamma-aminobutyric acid 100 mg
(from 129 mg Pharma GABATM 80 Complex )

Chew 1–2 tablets up to 3 times per day or as directed by a health professional.

Avoid taking in case of known allergy to any of the ingredients in the product. Consult a healthcare practitioner. Do not use if safety seal is broken. Keep out of reach of children.

AOR L-Tyrosine is an amino acid found in wheat germ, oats, dairy products, pork and poultry. It is a precursor for the neurotransmitters epinephrine, norepinephrine, and dopamine, which are all essential for mood, cognitive function and central nervous system function. The most prevalent usage for supplemental L-tyrosine appears to be the enhancement of cognitive function and alertness under conditions of environmental stress such as sleep deprivation, multi-tasking in the workplace, and functioning at high altitudes and/or cold temperatures. It is noteworthy to mention that a high percentage of the studies done on L-tyrosine are conducted by the military looking to enhance focus and attention in their personnel. Clinical trials with L-tyrosine have also been conducted with respect to attention deficit disorder (ADD) with good results. L-Tyrosine is also used by the body to make thyroid hormones as well as melanin, the skin and hair pigment.

L-Tyrosine is ideal for those who are required to work long hours under stressful conditions, those whose lifestyles or work require a high degree of multitasking, those who experience prolonged physical and mental stress, students, and those who have difficulty concentrating such as in ADD. 

• An Amino Acid for Stress Management
• Supports performance during prolonged, high-stress work
• Enhances cognitive function and alertness during multitasking and sleep deprivation AOR offers a potent and effective daily dose

Each veg-capsule contains:
Medicinal ingredient:
L-Tyrosine 600mg.

Non-medicinal ingredient:
Veggie capsule (hypromellose).

AOR guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.

Take 6 capsules in the morning on an empty stomach, or as directed by a qualified healthcare practitioner.

For prolonged use, consult a healthcare practitioner. Supplemental L-tyrosine may increase blood pressure or lead to difficulty sleeping in some persons. Consult a healthcare practitioner prior to use if you have hyperthyroidism, Graves’ disease or active melanoma, or if you are taking dopamine, thyroid hormone medication, contraceptives or other psychoactive medications. Do not use if you are pregnant or breastfeeding, or have the genetic metabolic disorder phenylketonuria (PKU). Discontinue use if you experience nausea, headache, fatigue, heartburn or joint pain.

5-HTP is a break-down product of the amino acid tryptophan. Proteins in our food provide us with amino acids, one of which is tryptophan. Tryptophan is broken down into 5-HTP and then 5-HTP is turned into serotonin. Serotonin is the neurotransmitter that makes you happy and tells your brain that you are satisfi ed so that you do not need to eat anymore. Serotonin deficiency contributes to weight gain, anxiety, depression, sleeplessness and panic attacks. Low serotonin levels also lead to carbohydrate (sugar) cravings and overeating. 5-HTP reduces appetite while also enhancing mood and increasing energy levels.

• Improves mood
• Enhances serotonin, our happy hormone
• Reduces PMS symptoms
• Reduces severity and duration of migraines
• Reduces menopausal stress
• Aids restful sleep
• Reduces menopausal stress
• Provides fibromyalgia relief
• Reduces panic attacks
• Aids weight management

Each veg-capsule contains:
Medicinal ingredient:
5-Hydroxytryptophan (5-HTP) (griffonia simplicifolia) (seed extract) (99% pure 5-hydroxytryptophan) 100mg.

Take1-2 tablets before breakfast, dinner and bedtime on an empty stomach or as directed by a healthcare practitioner.

If you are taking MAO inhibitors, SSRIs (Prozac, Luvox, Paxil, Effexor, Zoloft) and/or the tricyclic antidepressants (Elavil, Tofranil, Pamelor) or St. John's wort, do not take 5-HTP without discussing it with your health care provider. 5-HTP can be used to wean off antidepressants. Discuss any medication changes with your health care provider. If you wish to wean off your antidepressant medication using Smile, advise your doctor that you want a prescription for progressively lower doses of your antidepressant medication. Let your doctor know you are going to use Smile 5-HTP as a replacement. You can start weaning off your medication over a 4 week period. During week one, take 100 mg of Smile in the morning and at bedtime. In week two, lower your dose of antidepressant medication and take 100mg of SMILE at morning, dinner and bedtime. Then in week three, your dosage of antidepressant medication should be lowered again and you can take 100mg of SMILE at breakfast, 100mg before dinner and 200 mg at bedtime. In week four, you will be on a very low dose of antidepressant medication and will need to take 200mg of Smile before breakfast, dinner and bedtime. In week five, you are no longer on antidepressant medication and now you can stay on Smile. Take one scoop of Magsmart at bedtime during this process to ensure that you do not experience side effects from withdrawal of the antidepressant medication. Keep out of reach of children.

Sleeping well and feeling good are two of life’s necessities that keep us healthy and happy. But sometimes we need a little help maintaining both, and if we can get relief from a single source, all the better. CanPrev’s 5-HTP 100 is formulated from three key ingredients that work synergistically to promote restful sleep and healthy mood. 5-HTP 100 also works to help relieve symptoms of fibromyalgia (pain, anxiety, morning stiffness and fatigue) and reduce the severity and duration of migraine and tension headaches when taken as a preventative. Can one product do all that? Absolutely.

5-hydroxytryptophan (5-HTP) is a compound made in the body from the amino acid, tryptophan, that you get from eating protein-rich foods. Once in the 5-HTP state, it goes on to form serotonin, the neurotransmitter that helps regulate mood and behaviour, and then is further metabolized into melatonin. Yes, you can depend on tryptophan as a precursor to the development of serotonin, (think protein-rich hot chocolate before bed) but research has shown 5-HTP to be much more efficient at delivering the feel-good hormone to the brain. Serotonin guided by tryptophan on its own is not able to break through the blood brain barrier (your brain’s defense system for keeping out foreign substances) but 5-HTP can. It acts as the password for serotonin to get past the security gates and flood the brain with its mood lifting and sleep inducing properties.

CanPrev’s 5-HTP 100 is sourced from the African plant Griffonia simplicifolia and enhanced with vitamin B6 and Magnesium which are important cofactors to help the body convert and utilize 5-HTP.

• Helps to promote healthy mood balance, relieve symptoms of fibromyalgia
• Reduces the severity and duration of migraine headaches when taken as a prophylactic
• Can be taken as a sleep aid

Each veg-capsule contains:
Medicinal Ingredients:
5-HTP (5-Hydroxy-L-tryptophan) 100mg, magnesium (magnesium bisglycinate) 60mg and vitamin B6 (pyridoxine HCl) 33.3mg.

Non-Medicinal Ingredients:
Vegetable-grade magnesium stearate and vegetable capsule.

Consult a healthcare practitioner for use beyond 1 year. Contraindicated in those with scleroderma. Caution advised during pregnancy and breastfeeding. User should discontinue use and consult a healthcare practitioner if signs of weakness, oral ulcers, skin changes or abdominal pain accompanied by severe muscle pain occur, or if sleeplessness persists continuously for more than 3 weeks.

Caution advised when used concurrently with carbidopa or drugs or supplements with serotonergic activity. These may include, but are not limited to, antidepressants, L-tryptophan, S-adenosylmethionine (SAMe), St. John’s wort, painkillers, anti-nausea and anti-migraine medications, and over-the-counter cough and cold medications containing dextromethorphan.

Diarrhoea, nausea, vomiting, abdominal pain or drowsiness may occur. User should exercise caution if operating heavy machinery, driving a motor vehicle or involved in activities requiring mental alertness.

5-HTP is primarily used to support mood through its ability to boost serotonin levels. It has been compared to various tricyclic antidepressants, and has been found to be as effective with fewer side effects and quicker effectiveness. Since serotonin and melatonin are involved in regulating the sleep/wake cycle, 5-HTP also enhances sleep quality. Additionally, research supports a role for 5-HTP in reducing migraines and the symptoms of fibromyalgia.

Studies in Spain and Italy found that 5-HTP was comparable to the drug methysergide in alleviating the symptoms of migraines (over 70% in both groups) while eliciting considerably fewer side effects. Fibromyalgia patients have been found to have low serotonin levels and have shown symptomatic improvement with the use of tricyclic and SSRI antidepressants. Several clinical trials have confirmed significant improvements in symptoms, including pain, morning stiffness, nervousness, and fatigue.

• A precursor to serotonin
• Supports healthy mood balance and sleep patterns
• Helps alleviate migraines and fibromyalgia
• Flexible dosing options for varying needs

L-5-Hydroxytryptophan (griffonia seed extract) - 50 mg

Non-medicinal Ingredients:
microcrystalline cellulose, sodium stearyl fumarate. Capsule: hypromellose.

For healthy mood balance, take one to two capsules three times daily with food; for relief of symptoms of fibromyalgia, take two capsules three to four times daily with food. To minimize gastrointestinal side effect risk, start at 50 to 100 mg two to three times daily and slowly increase to an effective dose over two weeks.

Use for a minimum of one week to see beneficial effects for mood balance and two weeks for the alleviation of fibromyalgia symptoms. Consult a health care practitioner if symptoms persist or worsen or for use beyond one year.

Consult a health care practitioner prior to use if taking carbidopa or drugs/supplements with serotonergic activity, including, but not limited to, L-tryptophan, SAMe, St. John’s Wort, antidepressants, pain killers, cough/cold medication containing dextromethorphan, anti-nausea medication or anti-migraine medication. Some people may experience gastrointestinal disturbances such as diarrhea, nausea, vomiting and abdominal pain. May cause drowsiness; exercise caution if driving or operating heavy machinery or engaging in activities requiring mental alertness. Discontinue use and consult a health care practitioner if you experience skin changes, weakness, oral ulcers, or abdominal pain accompanied by severe muscle pain.

Do not use if you have scleroderma, if you are pregnant, breastfeeding, or trying to conceive. Not to be used by individuals under the age of 18 or those with a medical condition. This product contains corn, do not use if you have an allergy. Consult a health care practitioner if symptoms persist or worsen or for use beyond one year.

Sleep is a vital part of health and many of us are not getting enough. The 2002 Canadian Community Health Survey found about 1 in 7 adults has difficulty falling asleep or staying asleep. Insomnia affects 1 in 3 seniors and is 40% more common in women. Changes in sleeping patterns are largely reflective of our circadian rhythms, which are guided by the pineal hormone, melatonin. Melatonin is also known to decline as we age, which accounts for a number of the sleep changes we experience throughout life. Additionally, jet lag and shift work can significantly alter circadian rhythms and thus melatonin secretion.

In the face of insomnia, many people have tried prescription sleeping pills, but they can interfere with REM sleep, disrupt deeper stages of sleep and lead to confusion, sluggishness, anxiety and even drug dependency. Conversely, Melatonin has shown clinical benefit for inducing sleep or adjusting sleep cycles reducing sleep onset latency and improving perceived quality of sleep, without impairing daytime psychomotor performance or creating dependency. In fact, supplemental melatonin and bright light therapy are considered standard medical treatment for cases of jet lag, shift work, age-related insomnia, delayed sleep-phase disorder, advanced sleep-phase disorder, and non-24-hour sleep-wake disorder. Chronic sleep disturbance is a risk factor for premature aging, diabetes, obesity, cardiovascular disease and demonstrating just how important it is to maintain normal melatonin levels to enhance sleep quality.

• Derived from non-animal sources
• Refreshing, natural peppermint flavour
• A singular high potency sublingual tablet is optimal for those who need higher doses of melatonin (10-20mg)
• 30 to 60% of an oral dose of melatonin is metabolized via the liver and overall gastrointestinal absorption is variable

Each tablet contains:
Medicinal ingredient:
Melatonin (vegetarian Source) 3mg.

Non-Medicinal Ingredients:
Lactose monohydrate, microcrystalline cellulose, natural peppermint flavour, croscarmellose sodium and vegetable grade magnesium stearate (lubricant).

Adults: Dissolve 1 tablet under the tongue at bedtime once per day or as directed by a healthcare practitioner. Consult a healthcare practitioner for use beyond 4 weeks.

Consult a healthcare practitioner prior to use if you have a hormonal disorder, diabetes, liver or kidney disease, cerebral palsy, seizure disorders, migraine, depression and/or hypertension, or if you are taking blood pressure or sedative/hypnotic medications. Do not use if you are taking immunosuppressive drugs and/or if you are pregnant or breastfeeding. Do not drive or use machinery for 5 hours after taking melatonin. If symptoms persist continuously for more than 4 weeks (chronic insomnia), consult your healthcare practitioner. Keep out of reach of children.